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Deletion of CD38 and Supplementation of NAD Attenuate Axon Degeneration in a Mouse Facial Nerve Axotomy Model

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Approximately 95% of primary bile acids are reabsorbed through the terminal ileum sodium-dependent bile acid transporter and enter the enterohepatic circulation, while the remaining 5% are metabolized by bile salt hydrolases and 7α-dehydroxylases secreted by Bacteroides , Clostridium , Bifidobacterium , and Lactobacillus into secondary bile acids such as deoxycholic acid and lithocholic acid (Ridlon et al., 2016)