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Hypoxia may also increase susceptibility to kidney injury 8 and contribute to the progression of chronic kidney disease (CKD) 18,19 , although controversy exists as to the causality of this association 20
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Further experiments demonstrated that cholestasis-related primary BAs, including tauro-β-muricholic acid (Tβ-MCA) and glycocholic acid (GCA), facilitated the immunosuppressive phenotype conversion of neutrophils via the p38 MAPK signaling pathway (89)
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