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Figure 5 While immune complexes are known to be immunogenic, immune complex-mediated immunogenicity is typically driven by mechanisms that are lacking from the aglycosylated SEFL Fc domain of AMG 966, such as FcγR binding ( in vitro and assessed binding to FcγRIa, FcγRIIa, and FcγRIIIa compared to AMG 966 alone in a competitive AlphaLISA binding assay

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doi: 10.1016/S0378-4274(03)00116-4

Studies show glutathiones detoxifying and skin