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231 Additionally, approximately one-third of the pathological mutations observed in the gene encoding tau (MAPT) have been reported to affect tau splicing and the ratio of tau isoforms containing three or four microtubule-binding domains (3R-tau to 4R-tau ratio)—a ratio whose imbalance is linked to impaired microtubule dynamics in tauopathies such as AD
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If this level was used as in the experiments above, the mice would have been injected with 0.2 ml of liquid containing 0.68 nanograms of GHK
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