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As the pituitary reduces its output of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) , natural testosterone production falls, sperm production can decline or stop, and the testes can shrink

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Figure A.8.1 - Hazard Categories for Specific Target Organ Toxicity Following Single Exposure CATEGORY 1 : Substances that have produced significant toxicity in humans, or that, on the basis of evidence from studies in experimental animals can be presumed to have the potential to produce significant toxicity in humans following single exposure Substances are classified in Category 1 for STOT-SE on the basis of: (a) Reliable and good quality evidence from human cases or epidemiological studies