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Metabolic Perturbation# While increased NAD+ is generally considered beneficial, the broader metabolic consequences of NNMT inhibition -- including effects on polyamine metabolism, one-carbon metabolism, and other SAM-dependent pathways -- have not been systematically evaluated

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Mechanistically, the glutamate-induced oxidative cytotoxicity is mediated via two different pathways, namely, the receptor-mediated excitotoxicity and the non-receptor-mediated oxidative cytotoxicity 33,34,35,36

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