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This loss of symmetry, evidenced by the emergence of a side cleft between protomers of the LBD dimer, is a hallmark of desensitization of AMPARs in complex with auxiliary subunit GSG1L which slows the recovery from desensitization substantially (Twomey et al., 2017b

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Gritstone Biotech employed Venezuelan equine encephalitis virus-based self-amplifying mRNA vector in a lipid nanoparticle called GRT-R910 encoding both the prefusion stabilized full-length SARS-CoV-2 spike and additional conserved T-cell epitopes from ORF3a, NP and membrane (Table 3)