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These were carried out in rats with occluded major vessel(s), peripherally [129,130,131,132] or centrally [133], which underwent similar noxious procedures [134,135,136,137] and various damaging agent applications [138,139,140,141,142,168]
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However, as Moncrieff and colleagues point out in an attractive systemic review, there is no convincing evidence that depression could be associated with or caused by lower serotonin concentrations or activity [94]
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