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Furin plays a major role in oocyte development beyond the early secondary follicle stage and any virus-mediated loss of its proteolytic activity could lead to follicular dysplasia and female infertility 354
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These reactions are actually quite slow unless catalyzed by an enzyme such as protein disulfide isomerase (PDI), an important enzyme that is particularly abundant in the endoplasm reticulum where protein folding occurs
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