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In the model of mouse skin treated by stage I tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate, NDGA pretreatment mitigated cutaneous lipid peroxidation, inhibited H 2 O 2 production, restored reduced GSH level and activatied antioxidant enzymes, lowered the elevated activities of myeloperoxidase (MPO), xanthine oxidase and skin edema formation, thereby demonstrating antioxidative and anti-inflammatory properties and chemopreventive potential against skin cancer [64]
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