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The intrinsic pathway involves mitochondrial release of pro-apoptotic factors (apoptogens), such as cytochrome c and apoptosis-inducing factor (AIF), from the intermembrane space and antiapoptotic Bcl-2 family members (Bcl-2, Bcl-XL) that prevent the apoptosis-associated release of apoptogens (277, 319)

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NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus