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For AOD-9604 specifically, the disulfide bond is also susceptible to oxidation at warmer temperatures if any oxygen is present

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By separating the lipolytic C-terminal region, researchers produced a compound with concentrated fat-metabolism activity and a significantly reduced side-effect profile compared to recombinant GH — particularly with respect to insulin sensitivity and IGF-1 axis stimulation, which are primary concerns with full GH administration in research models