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10.1021/acs.jmedchem.0c00280 87 XiaoQ.MaiB.NieY.YuanC.XiangM.ShiZ.et al (2021)

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Leveraging the proximity effect enabled by this fibrillar framework, CRBN anchored on the network simultaneously mediates ubiquitination tagging of both AR and HSP90, thereby establishing a supramolecular platform for coordinated polyubiquitination and subsequent degradation of compartmentalized oncoproteins 30,33,46 (Fig