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Cell 16 , 984–996 (2005)

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You should speak to your GP if you notice: Unexplained or rapid weight gain, particularly around the abdomen, face, or upper back A rounded, 'moon-shaped' face or a fatty hump between the shoulders Stretch marks that are wide, purple, or reddish in colour Unusual fatigue, muscle weakness, or difficulty with everyday physical tasks Persistent high blood pressure or blood glucose problems Mood changes, depression, or anxiety that feel disproportionate or difficult to manage Skin darkening (hyperpigmentation), salt craving, dizziness on standing, or unexplained weight loss alongside low blood pressure — these may suggest adrenal insufficiency These symptoms may warrant investigation for conditions such as Cushing's syndrome or adrenal insufficiency, which require specialist endocrinological assessment