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constructed a metal–phenolic network (TBFP-MT MPN) system based on PEG-polyphenol, which reduces drug efflux by inhibiting mesenchymal–epithelial transition signaling and blocking pyrimidine synthesis through the inhibition of dihydroorotate dehydrogenase (DHODH), thereby lowering the levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and enhancing TMZ cytotoxicity (149)