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Introduction Nitric oxide synthase (NOS) exhibits two alternative activities depending on the relative availability of its cofactor tetrahydrobiopterin (BH4) ( Figure 1 ) In the presence of sufficient BH4, NOS catalyzes the production of NO and citrulline from the amino acid arginine

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doi: 10.3892/or.2015.3727 102 YilmazMKantarjianHRavandiF