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Furthermore, the data showed that both the ROS scavenger N -acetylcysteine (NAC) and GSH compensator GSH-MEE could abrogate APR-017 and LCS3 induced increase in ROS, decrease in GSH and inhibition of cell growth in VRK2-KO cells (Fig

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Results The results show that there was a significant increase in plasma corticosterone, serum lipid peroxidation and nitric oxide level along with a decrease in enzymatic and non-enzymatic antioxidant as well as significant decrease in interleukin 2, tumor necrosis factor-α and interferon-γ