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By limiting iron availability, LF also affects tumor metabolism—it reduces ferritin and transferrin receptor 1 (TfR1) expression, which limits iron uptake by cancer cells, while increasing ferroportin levels, facilitating the removal of iron from cells

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10.1016/j.bbadis.2011.12.012 [DOI] [PubMed] [Google Scholar] 118.Corti A, Franzini M, Cianchetti S, Bergamini G, Lorenzini E, Melotti P, et al