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Lack of Identified Gene and Receptor The most scientifically unusual gap in DSIP research is the continued absence of an identified encoding gene or specific receptor: No DSIP gene has been isolated in any species, including those where the peptide was originally discovered No specific DSIP receptor has been characterized or cloned It remains unclear whether DSIP itself is the primary bioactive agent or a proxy for an unidentified endogenous DSIP-like peptide Many attributed effects may be mediated by structurally related endogenous peptides rather than DSIP directly Inconsistent Human and Clinical Data Human study findings are limited in scope and reproducibility: All controlled human studies used intravenous administration