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Signals from the gut influence appetite, satiety, and energy balance through: The vagus nerve Hormonal signaling Microbial metabolites Key metabolic hormones produced or influenced by the gut include: GLP-1 (glucagon-like peptide-1) – enhances insulin secretion and promotes satiety Peptide YY (PYY) – signals fullness Ghrelin – stimulates hunger When gut health is disrupted, these signals can become dysregulated, potentially contributing to overeating or impaired metabolic control