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Treatment of 4T1 cells with 10 μM 4HT for 24 h significantly increased the conjugation of proteins at 65 kDa with 4HNE and this effect was partially blocked with the antioxidants, vitamin E and/or PMC (2,2,5,7,8-pentamethyl-6-chromanol, a vitamin E moiety without a lipid tail) (Fig
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Accordingly, the excessive Zn 2+ could disrupt redox balance within cells, leading to apoptosis and cytoskeletal remodeling
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