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Although treatment strategies have improved, the survival rate remains low, highlighting the urgent need for further research to understand the disease’s underlying mechanisms better and to develop more effective treatment options (Zhang et al., 2022)

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22 Similarly, the lactylation of methylated CpG-binding protein 2 (MeCP2), a nuclear protein selectively recognizing and binding to DNA, inhibits epiregulin (Ereg) transcription and the subsequent Egfr/MAPK pathway