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TF is a 47 kDa integral membrane GP that initiates the extrinsic pathway by forming a complex with FVIIa [86]

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Reductive methylation of cobalamin to methylcobalamin is done using methionine synthase reductase in which SAMe acts as a methyl donor Once cobalamin enters the mitochondria, it's adenosylated to make adenosylcobalamin

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