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Research from Ng and colleagues (published in Molecular and Cellular Endocrinology, 1990s) identified this region as responsible for GH's lipolytic activity, separate from the receptor-binding domains at positions 1 to 175 that drive IGF-1 production and diabetogenic effects

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Without BPC-157, TB-500 sends cells into a hypovascularized area, where they eventually die before rebuilding the tissue