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Interestingly, several fragment hits originating from our second XChem screen possess alternative groups to the sulfonic acid that interact with R131 and R102, which opens up opportunities to link and merge hit matter found across the TIN2 leucine and phenylalanine binding pockets

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In preclinical research environments, GHK-Cu has been studied for its interaction with redox-sensitive signaling pathways, transcriptional regulation mechanisms, and matrix-associated cellular communication networks