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Our analysis highlights a central role of glycolysis, with key genes such as aldolase, fructose-bisphosphate A ( ALDOA ), hexokinase 2 ( HK2 ), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ( PFKFB3 ), and lactate dehydrogenase A ( LDHA ) forming highly connected hubs, reflecting a metabolic shift toward anaerobic glycolysis as the primary pathway for ATP production

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