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Surface plasmon resonance analyses provide direct evidence of melittin’s interaction with these critical upstream signaling molecules, with dissociation constants of 4.6 × 10 -6 M (IKK α ), 1.34 × 10 -9 M (IKK β ), and 1.01 × 10 -9 M (p50), highlighting its specificity and potency (90, 91)