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Complete topological mapping of a cellular protein interactome reveals bow-tie motifs as ubiquitous connectors of protein complexes
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Although no model perfectly reproduces the human condition, carefully designed preclinical systems offer unique opportunities to investigate mechanistic pathways, test hypotheses, and evaluate novel interventions under controlled conditions that are not feasible in humans for ethical, practical, or technical reasons [63, 64, 65, 66, 68]
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