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For ProBio PCC, we selected a unique strain called Lactobacillus fermentum PCC that met our criteria of pH survival (ability to survive the acidic pH of gastric juices and bile), intestinal colonization (ability to colonize in the gut), identity, and dosing

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In this context, the increased permeability of gastrointestinal epithelial cells frequently results from the destruction of tight junctions (TJ), and release of different pro-inflammatory mediators, including ROS and RNS, which actively contribute to the pathogenic cascade that initiates and perpetuates the inflammatory response in the gut [44]