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The scientific conundrum of which came first, Aฮฒ or OS, would be a moot issue if early reversal of OS prevents Aฮฒ deposition and neurofibrillary tangle formation before their burden causes clinical symptoms [38,133,155]
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This proposal is consistent with the role of 5-HT as a neuromodulator, and that dysregulation of the 5-HT system in depression and anxiety represents a biological risk factor rather than being the primary cause of psychopathology
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