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Red Flags After a Calf Injury Not every calf injury leads to a rupture, but these signs may suggest you’re at elevated risk: Persistent tightness or stiffness despite rest and rehab Recurring twinges during explosive movements A “knot” or focal tenderness deep in the lower calf Feeling of weak push-off when sprinting or jumping A calf that “feels fine” until game-speed effort then fails Haliburton’s case highlights this last point vividly: full-speed intensity after a season of managing a calf issue is a dangerous setup

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Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons