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In this manner, mutant p53 is believed to contribute to the propensity of tumor cells to utilize aerobic glycolysis in favor of oxidative phosphorylation, or so-called Warburg metabolism ( A Common Genetic Variant in TP53 Influences its Function in Metabolism There is a common coding region polymorphism of p53 at codon 72, encoding for either proline (P72) or arginine (R72)
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