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These OMG differences for each DEG were compared to the OMG differences for all 4 HKGs

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Glutathione reductase and glutathione peroxidase (GSH-Px) activities were measured using GSSG/NADPH and cumene hydroperoxide as substrates respectively as described previously ( Measurement of microsomal cytochrome P450 2E1 and 3A4 enzymes Cytochrome P450-dependent monooxygenase enzymes play important roles in maintaining redox homeostasis and detoxification of various drugs