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In further embodiments, the invention encompasses a method of treating an NNMT-expressing cancer such as glioblastoma, by administering a therapeutically effective amount of one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1cβ², 1fβ², 1lβ², 1mβ², 2jβ², 2kβ², 2lβ², 2mβ², and 2aaβ²
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