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Systemic Rejuvenation In landmark studies (Baar et al.), FOXO4-DRI administration in aged mice reversed signs of frailty, restored fur density, and improved renal function by clearing senescent cells from tissues

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(2016) described that, besides activating GABA B receptors in astrocytes, GABA release by interneurons also activates GABA A receptors in presynaptic neurons, which inhibited synaptic activity