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Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry | Translational Psychiatry

In addition to the regulation of this main transcription loop, CLOCK/BMAL1 stimulates the expression of other clock-related transcriptions, such as REV-ERB α, retinoic acid-borne orphaned binders a ( ROR α), DEC1 , DEC2 , and albumin D-binding ( DBP ), which form an auxiliary loop that stabilizes the main regulatory loop (Ripperger and Schibler, 2006

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Restoring glutathione availability may lower oxidative burden, but clinical translation depends on concurrent micronutrient repletion (selenium, zinc, iron) and resolution of the primary inflammatory driver