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In mice, CHAC1/BOTCH promotes neuronal differentiation by inhibiting NOTCH1 and both its depletion and overproduction severely disrupt neurogenesis ( CHAC1/BOTCH in zebrafish leads to severe defects in brain, heart and myotome development, resulting in embryonic lethality, highlighting its conserved and essential role (Yadav et al., 2019)
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p16∷3MR mice and the peptide FOXO4-DRI are subject to patent applications and may be shared with research organizations for research and educational purposes only under an MTA to be discussed in good faith with the recipient
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