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Frontiers | Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome
By engaging AMPK and promoting substrate oxidation, MOTS-c complements the lipolytic and GH-releasing arms of the blend, allowing researchers to study how convergent mitochondrial, pituitary, and adipocyte signalling integrate to regulate whole-organism energy balance in preclinical models
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