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Despite MDMA and psilocybin’s categorization as Schedule I substances, the US Food and Drug Administration (FDA) has more recently granted Breakthrough Therapy designation to MDMA-assisted psychotherapy (MAP) for Posttraumatic Stress Disorder (PTSD) as well as psilocybin-assisted psychotherapy (PAP) for both Major Depressive Disorder (MDD) and Treatment-Resistant Depression (TRD)

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Muscle preservation Some formulations include glycine along with b12, claiming this combination preserves muscle mass during weight loss