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however, evidence regarding the function of HSCs in CRC is lacking, and the specific regulatory mechanisms require further exploration

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The PLS-DA and heat map in Figure 1 show that resistant cells treated continuously with 1 µM tamoxifen (4+1), a concentration that is often measured in patients (24), showed different metabolic clusters compared to the other two resistant groups (50 and 35x6) and the control (tamoxifen-sensitive) group, indicating that they had markedly different metabolic characteristics ( Figure 1A )