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The administration of Minoxidil and IWR-1, which is an antagonist of Wnt signaling, was also performed in accordance with prior reports (15,16)

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Thus, it is obvious that Nrf2 and NF-κB interplay in neurodegenerative disorders, in which the increase of NF-κB aggravates neuroinflammation while the increase of Nrf2 affords neuroprotection (Sivandzade et al., 2019)