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Thus, while epigenetic alterations can arise both as direct consequences of DNA damage and as adaptive mechanisms supporting repair (Ying et al., 2024), epigenetic drift is primarily downstream of DNA damage, but once established, these alterations can further impair expression of DNA repair genes, antioxidant systems, and chromatin integrity, creating a feedback loop that exacerbates genomic instability (Xie and Jarosz, 2018)
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The reduced GSH levels could potentially impair the cell’s ability to protect against oxidative damage, which is especially critical for reproductive cells as they are highly sensitive to oxidative stress (28)
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