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Conversely, enterohepatic circulation is reduced by establishment of enteral nutrition, by increasing the frequency of feeding,98 by oral feeding of agar, which binds bilirubin in the gut,99 and by oral administration of bilirubin oxidase.100 It should be noted that the latter two treatments must be considered “off-label” and have not been subjected to any approval process of which we are aware
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This may in part reflect the idea that the immunoregulatory quality of DAMPs released by ferroptotic cells seem to substantially differ from immunogenic forms of cell death
