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In unadjusted models, the odds ratios (ORs) for gallstone risk were 0.96 (95% CI 0.94–0.99) for vitamin E, 0.73 (95% CI 0.61–0.88) for vitamin B6, and 0.96 (95% CI 0.95–0.98) for niacin

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Given that the affinity of antibodies is generally low, this indicates FOXO4-DRI effectively enters senescent cells at high intracellular concentrations, which remain abundant and stable over a prolonged period of time