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In adipose tissue, Roberti, Fernández, and Fraga, writing in Molecular Metabolism in 2021, established that NNMT sits at the crossroads of cellular metabolism and epigenetic regulation: its activity directly affects the methyl economy that governs gene expression and energy metabolism in fat cells
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Analyses used SAS version 9.3 mixed-effects regression models to estimate the effect and effect size of the treatment (Laird and Ware, 1982)
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