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Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity

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While the mechanisms continue to be debated, there are known structures of a number of these regulatory domains, including RCK domains of prokaryotic [73] [74] [75] and eukaryotic [70] [71] [72] channels, pH gating domain of KcsA, [76] cyclic nucleotide gating domains, [77] and voltage gated potassium channels