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Oral Phosphodiesterase-5 Inhibitors (PDE5I) Medications Oral medication for ED refers most of the time to PDE5 inhibitors, which remain the first-line treatment for ED and include: Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra) Their primary mechanism of action involves the inhibition of the enzyme phosphodiesterase type 5 (PDE-5), which is found in the smooth muscle cells of the penis

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