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RSL3 can directly inhibit GPX4 activity, inducing ferroptosis, as the electrophilic RSL3 binds to the nucleophilic portion of the selenocysteine residue in GPX4’s active site, impairing the glutathione cycle ( 2.2.2.2 FSP1/CoQ10/NADPH pathway Ferroptosis Suppressor Protein 1 (FSP1), an NAD(P)H-ubiquinone reductase, is the second major ferroptosis regulator discovered after GPX4

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Psoriasis, a common chronic inflammatory dermatosis, impacts 1–3% of the world’s population