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In addition, antioxidants may interfere with regulators of cell proliferation such as extracellular signal-regulated kinase 1/2 (ERK1/2), cyclin-dependent kinases regulating the cell cycle (Kim et al

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In LPS-stimulated RAW 264.7 cells and in a carrageenan-induced hind paw edema assay, syringaresinol downregulated NF-κB expression by interfering with JNK and p38 phosphorylation followed by the decrease in mRNA levels of iNOS, COX-2, TNF-α, IL-1β, and IL-6, thus suggesting its significant therapeutic potential [207]