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However, considering that maximal GPX activity occurs at 70–90 μg/L, and that maximal selenoprotein P levels occur closer to 120 μg/L, many recent studies have suggested a narrower Se range of 70–130 μg/L ( Serum/plasma total Se concentrations can be influenced by sex, age, smoking, water and diet Se content, dietary sources of Se (organic or inorganic), and various conditions that increase its demands or decrease its intake/utilization, leading to decreased Se concentrations (e.g., inflammation, anorexia, intestinal malabsorption syndromes, and total enteral or parenteral nutrition without adequate Se dosing) ( Serum/plasma/whole blood Se pool is insatiable
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